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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
POLE
All Species:
4.55
Human Site:
S2174
Identified Species:
11.11
UniProt:
Q07864
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.22
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q07864
NP_006222.2
2286
261518
S2174
L
D
L
C
K
D
S
S
F
S
E
D
G
A
V
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_543348
2273
260734
A2161
L
D
L
C
K
E
F
A
F
S
Q
D
G
A
V
Cat
Felis silvestris
Mouse
Mus musculus
Q9WVF7
2283
262009
S2171
L
D
L
C
K
D
S
S
F
S
Q
D
G
A
I
Rat
Rattus norvegicus
NP_001100622
1515
174729
M1411
L
H
R
T
L
H
N
M
M
K
K
L
F
L
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_001233985
2277
260654
A2165
L
D
L
C
K
D
P
A
L
S
Q
D
G
S
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001121995
2284
262166
A2176
L
D
L
C
K
D
P
A
V
S
Q
D
G
S
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_524462
2236
256683
K2128
D
L
D
L
C
K
D
K
H
R
A
M
K
D
G
Honey Bee
Apis mellifera
XP_393171
2183
252634
C2079
E
V
E
W
K
D
P
C
I
S
L
I
L
P
E
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002328167
2221
254636
R2113
C
R
D
L
D
L
C
R
D
S
A
V
L
A
E
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P21951
2222
255653
I2117
Y
C
F
F
I
S
D
I
D
F
C
K
A
A
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
N.A.
90.7
N.A.
90.5
60.7
N.A.
N.A.
83.7
N.A.
80
N.A.
55.2
54.6
N.A.
N.A.
Protein Similarity:
100
N.A.
N.A.
94.6
N.A.
95
63.5
N.A.
N.A.
92
N.A.
90.2
N.A.
71.9
71.5
N.A.
N.A.
P-Site Identity:
100
N.A.
N.A.
73.3
N.A.
86.6
6.6
N.A.
N.A.
60
N.A.
66.6
N.A.
0
20
N.A.
N.A.
P-Site Similarity:
100
N.A.
N.A.
93.3
N.A.
100
20
N.A.
N.A.
86.6
N.A.
86.6
N.A.
0
20
N.A.
N.A.
Percent
Protein Identity:
43.5
N.A.
N.A.
N.A.
40.5
N.A.
Protein Similarity:
62.7
N.A.
N.A.
N.A.
60.1
N.A.
P-Site Identity:
13.3
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
13.3
N.A.
N.A.
N.A.
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
30
0
0
20
0
10
50
0
% A
% Cys:
10
10
0
50
10
0
10
10
0
0
10
0
0
0
0
% C
% Asp:
10
50
20
0
10
50
20
0
20
0
0
50
0
10
0
% D
% Glu:
10
0
10
0
0
10
0
0
0
0
10
0
0
0
20
% E
% Phe:
0
0
10
10
0
0
10
0
30
10
0
0
10
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
50
0
10
% G
% His:
0
10
0
0
0
10
0
0
10
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
10
0
0
10
10
0
0
10
0
0
10
% I
% Lys:
0
0
0
0
60
10
0
10
0
10
10
10
10
0
0
% K
% Leu:
60
10
50
20
10
10
0
0
10
0
10
10
20
10
10
% L
% Met:
0
0
0
0
0
0
0
10
10
0
0
10
0
0
0
% M
% Asn:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
30
0
0
0
0
0
0
10
10
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
40
0
0
0
10
% Q
% Arg:
0
10
10
0
0
0
0
10
0
10
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
10
20
20
0
70
0
0
0
20
0
% S
% Thr:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
10
0
0
0
0
0
0
10
0
0
10
0
0
30
% V
% Trp:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _